Hepatoprotective Effects of Curcumin

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Medical Updates: Curcumin prevents radiation-induces breast cancer
Medical Updates: Curcumin modulates tumor remission
Medical Updates: Curcumin and vitamin C inhibit free radicals
Medical Updates: Curcumin may inhibit inflammation/blood clots

Studies from throughout the world that can help you live longer

If you wish to obtain the full scientific abstracts for any of these studies for reference or to show your doctor, please send a self-addressed stamped envelope with $1 to: Life Extension Foundation, P.O. Box 229120, Hollywood, Fla. 33022, USA. You can also obtain these abstracts free from our website: www.lef.org.

A study evaluated the preventive effect of curcumin on breast cancer tumors, which were induced by radiation in rats. Mated rats were divided into two groups at day 11 of pregnancy. The control group was fed a basal diet, and the experimental group a diet containing 1% curcumin between days 11 to 23 of pregnancy. They were implanted with a synthetic estrogen pellet. The results showed a high incidence (70%) of the development of breast tumors in the control group. However, in the rats fed curcumin, the appearance of tumors was significantly reduced to 19%. In addition, the appearance of the first tumor was delayed by 6 months in the curcumin-fed group. The average latent period until the appearance of tumors was 2.5 months longer in the curcumin-fed group. The proportion of cancer from cell walls of breast gland (17%) in total tumors in the curcumin-fed rats was decreased to half that (32%) in the controls. The blood concentrations of fatty acids, TBARS (a stress marker) and ovarian and pituitary hormones, remained the same at the control group level. There was no toxicity from curcumin, and no change in litter size and body weight of pups born from curcumin-fed rats. The results suggest that curcumin is effective as a chemopreventive treatment at the radiation-induced initiation stage of breast cancer development and does not have any side-effects.

CARCINOGENESIS, 2000, Vol 21, Iss 10, pp 1835-1841

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Studies from throughout the world that can help you live longer

If you wish to obtain the full scientific abstracts for any of these studies for reference or to show your doctor, please send a self-addressed stamped envelope with $1 to: Life Extension Foundation, P.O. Box 229120, Hollywood, Fla. 33022, USA. You can also obtain these abstracts free from our website: www.lef.org.

Curcumin, the yellow pigment from the curcuma longa plant, has been shown to destroy tumors. Studies have shown that curcumin induces apoptosis (cell death) in rat macrophages (immune system cells), which leads to the inhibition of tumor growth in the body. The study suggested that the macrophages and natural killer cells play an important modulatory role in the remission of tumors. The study revealed that curcumin activates macrophages and natural killer cells (NK) during the spontaneous regression of transplanted tumors. Prolonged treatment with curcumin culminated in a stronger tumor-killing effect.

FEBS LETTERS, 2000, Vol 483, Iss 1, pp 78-82

Studies from throughout the world that can help you live longer

If you wish to obtain the full scientific abstracts for any of these studies for reference or to show your doctor, please send a self-addressed stamped envelope with $1 to: Life Extension Foundation, P.O. Box 229120, Hollywood, Fla. 33022, USA. You can also obtain these abstracts free from our website: www.lef.org.

Two naturally occurring antioxidants, curcumin and vitamin C, were effective in inhibiting formation of various industrial chemicals such as hexanal when fermented cucumber tissue were exposed to oxygen. The addition of vitamin C prevented formation of most of these oxidative aldehydes at 175 ppm or greater. Curcumin, which is used commercially as a-yellow coloring in cucumber pickle products, was found to almost completely prevent aldehyde formation at 40 ppm.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2000, Vol 48, Iss 10, pp 4910-4912

Studies from throughout the world that can help you live longer

If you wish to obtain the full scientific abstracts for any of these studies for reference or to show your doctor, please send a self-addressed stamped envelope with $1 to: Life Extension Foundation, P.O. Box 229120, Hollywood, Fla. 33022, USA. You can also obtain these abstracts free from our website: www.lef.org.

Curcumin is a naturally occurring polyphenolic phyto-chemical from the stem of the plant Curcuma longa. It possesses anti-inflammatory properties and inhibits cancer formation in mice. Many lipoxygenase inhibitors including curcumin are currently being studied for their anti-carcinogenic properties. (Lipoxygenase is an enzyme that modulates the conversion of arachidonic acid. It is the precursor for the creation of prostaglandins, thromboxanes and leukotrienes, which can cause complications such as inflammation and blood clots). Understanding how curcumin inhibits lipoxygenase may help in the development of novel anti-cancer drugs used for treatment where lipoxygenases are involved.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2000, Vol 6, Iss 5, pp 521-526

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