Vitamin D-3 blood levels and colorectal cancer

Vitamin D-3 blood levels and colorectal cancer

Studies have demonstrated an opposite relationship between dietary calcium plus vitamin D intake and the incidence of cancer of the colon and rectum. Elevated blood levels of vitamin D-3 are associated with a major reduction in the incidence of these tumors. Calcium supplements normally reduce tumor size and number, but this beneficial action was neutralized by a vitamin D-3 deficiency.

Vitamin D blood levels have not been determined previously in colorectal cancer patients. This study compared serum vitamin D-3, and parathyroid hormone (PTH) levels of 84 colorectal carcinoma patients (10 with Stage I, 29 with Stage II, 25 with Stage III, and 20 With Stage IV) and 30 healthy controls, all of whom were normocalcemic and not taking calcium or vitamin D supplements. Results showed blood vitamin D-3, and PTH levels higher in cancer patients than controls, irrespective of stage. Blood vitamin D-3 decreased with advancing stage of cancer: 73, 48, 39, 34, and 75 pg/mL in Stages I, II, III, IV and controls, respectively. There was a corresponding increase in blood PTH levels: 58.0, 73.7, 79.0, 100.4, and 51.2 pg/mL in Stages I, II, III, TV, and controls, respectively. Blood vitamin D metabolite levels did not correlate with gender, age, tumor localization, or histologic grade. Thus, an opposite relationship between blood levels of the active metabolite of vitamin D and colorectal cancer stage has been demonstrated for the first time, in colorectal cancer patients. Because vitamin D-3 has been shown to inhibit proliferation of colon cells, having decreased blood levels of vitamin D-3 may facilitate the growth of colon and rectal cancer and influence its biologic behavior.

Cancer, 1999, Vol. 86, Iss 3, pp 391-397

Article copyright Life Extension Foundation.

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