Effect of herbal medicine Dia-No on clinical and biochemical parameters of metabolic syndrome

Tagged:  

HERBS -- Therapeutic use
MATERIA medica, Vegetable
INSULIN resistance
HYPOGLYCEMIA
METABOLISM -- Disorders -- Treatment
BLOOD sugar

Abstract:Herbal preparations have attracted attention in the management of metabolic syndrome. Since time immemorial, medicinal plants have been used in virtually all cultures. The traditional herbs require scientific and medical evaluation. Ten classic herbs have been combined in Dia-No, a polyherbal preparation containing water extracts of its ingredients, known for their anti-hyperglycemic and anti-hyperlipidemic potential. Efficacy of Dia-No on clinical and biochemical parameters of metabolic syndrome was evaluated. Two hundred patients with metabolic syndrome were selected randomly after meeting inclusion and exclusion criteria. The patients were divided into two groups, one group receiving the drug and the other receiving a placebo bearing a distinctive code number. Anthropometric parameters, metabolic profile fasting blood sugar, HbA1c and lipid profiles were performed initially and after 3 months of treatment. Renal, liver function and any untoward effects were noted. After three months of treatment with Dia-No, there was a significant improvement in body mass index (BMI) (25.64±5.12 to 25.46±5.01, p<0.05), systolic blood pressure (135.89±18.48 to 133.60±14.52 mmHg, p<0.05) and fasting blood sugar (221.29±74.16 to 180.14±40.64, p<0.01). There was a significant reduction in HbA1c (9.07±2.04 to 8.47±1.90 %, p<0.01). Changes in triglyceride level, VLDL and LDL were also significant (159.54±28.09 to 148.95±27.07, p<0.01; 31.91±5.81 to 29.87±5.46, p<0.01 and 123.18±29.27 to 119.69±27.14, p<0.05 respectively) after treatment. No adverse effects were observed in this trial. The polyherbal preparation of 10 classic herbs appears to be effective in controlling glycemia and dyslipidemia. Dia-No seems to be a safe drug and an effective oral agent in the management of metabolic syndrome.

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