Fluoride and Non-Ulcer Dyspepsia

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Fluoride and Non-Ulcer Dyspepsia

Twenty patients with non-ulcer dyspepsia and ten age and sex matched controls had a gastroenterological evaluation which included biopsies and assessment for Helicobacter pylori. Fluoride levels in the drinking water were also evaluated. There were significantly higher levels of fluoride in patients with non-ulcer dyspepsia than controls. Seventy percent of the patients with non-ulcer dyspepsia had histological abnormalities in the antral and duodenal mucosa, compared to only one control subject. Fluoride levels in the serum and urine correlated with symptoms, histological and electron microscope abnormalities. The authors conclude that chronic exposure to fluoride may result in non-ulcer dyspepsia, and should be considered when other known causes of dyspepsia have been excluded.

Reference: "Fluoride as a Possible Etiological Factor in Non-Ulcer Dyspepsia", Gupta, I P, et al, Journal of Gastroenterology and Hepatology, 1992;7:355-356. (Address: Dr Rakesh K Tandon, Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India)

Health Action Network Society.

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By Kirk Hamilton

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