Phellodendron Bark Shows Multiple Anti-ulcer Activities


Phellodendron Bark Shows Multiple Anti-ulcer Activities

The bark of Phellodendron amurense was found effective against several types of ulcers, confirming another of its traditional uses. The bark has been used in Chinese medicine to treat gastroenteritis, diarrhea, and abdominal pain. One of the major components of the plant, berberine, has potent anti-bacterial activity, anti-inflammatory effect, and stimulates bile secretion. Berberine, also a component of Berberis (barberry) and Hydrastis (goldenseal), has long been a favorite among savvy travelers for knocking out food- and water-borne intestinal problems. Researchers T. Uchiyama et al., from Toyama Medical and Pharmaceutical University, previously reported an antiinflammatory activity in the berberine-free fraction of the Phellodendron bark. In the present study, they also found anti-ulcer activity in this fraction. This effect was tested on various types of ulcers, including those induced by alcohol and aspirin, as well as stress-induced ulcers. The authors note, "these findings suggest that the suppression of ulcer formation may be due to the additive effect of the cytoprotection effect and the reduction of gastric acid secretion by the administration Phellodendron extract was only half as effective as the positive control, atropine sulfate, and orally it was only 28 percent as effective as the atropine orally." Yakugaku Zasshi, 109(9), 672-676, (1989).

American Botanical Council.


By Rob McCaleb

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