Niacinamide's Potent role in Alleviating Anxiety with its Benzodiazepine-like Properties: A Case Report

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NICOTINAMIDE
BENZODIAZEPINES
LUNGS -- Diseases
DIABETES
HYPERTENSION
BUSPIRONE

Abstract:Anxiety disorders are extremely debilitating and are the most common psychiatric disorders in the United States. Such patients have greaser chances of developing other medical illnesses such as chronic obstructive pulmonary disease, diabetes and hypertension. The underlying anxiety that exists in these patients also tends to prolong the course of any additional medical illnesses that they may develop. The conventional approach to severe anxiety involves pharmaco therapy with benzodiazepines, selective serotonin re-uptake inhibitors (SSRIs,), or other medications such as buspirone, imipramine or trazodone. A case report demonstrated that the use of 2500 mg of niacinamide (nicotinamide) per day ameliorated severe anxiety in a 34-year-old male patient. It appears that niacinamide has therapeutic properties similar to size benzodiazepines. However, the therapeutic effects of niacinamide likely have little to do with it acting as a ligand for the benzodiazepine receptor. Niacinamide might exert its effects through its modulation of neuro-transmitters that are commonly unbalanced in those areas of the brain associated with anxiety. Niacinamide might also reduce anxiety by shunting more tryptophan toward the production of serotonin and/or by simply correcting a vitamin B3 dependency. The use of niacinamide for extended periods of time appears to be safe, but megadoses can cause sedation, nausea and vomiting. More case reports, research and rigorous controlled trials are needed to properly evaluate niacinamide's therapeutic effectiveness, safety and mechanisms of action for the treatment of anxiety.

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