Hormone Replacement with Estradiol: Conventional Oral Doses Result in Excessive Exposure to Estrone


BACKGROUND: There is a lack of consensus about the safety of estrogen replacement therapy, especially with regard to its impact on a woman's risk for breast cancer. Elevated urinary or serum estr...

Synthesis, Analysis and Biological Evaluation of Novel Steroidal Estrogenic Prodrugs for the Treatment of Breast Cancer


Breast cancer is the most prevalent type of cancer in pre- and postmenopausal women in most Western countries. In the treatment of metastatic breast cancer, doxorubicin has the broadest spectrum ...

Total and Monounsaturated Fat Intake and Serum Estrogen Concentrations in Premenopausal Japanese Women


The relationships between fat intake and serum estrone, estradiol, and sex hormone-binding globulin were examined cross-sectionally in 60 premenopausal Japanese women. Blood samples were collecte...

Flaxseed Consumption Influences Endogenous Hormone Concentrations in Postmenopausal Women


Lignans, similar in structure to endogenous sex steroid hormones, may act in vivo to alter hormone metabolism and subsequent cancer risk. The objective of this study was to examine effects of die...

Hormonal Response to Diets High in Soy or Animal Protein Without and With Isoflavones


Hormonal Response to Diets High in Soy or Animal Protein Without and With Isoflavones in Moderately Hypercholesterolemic Subjects

Abstract: Consumption of soy protein has been associated with altered risk of developing endocrine-regulated cancers. This study was designed to assess the independent effect of soy relative to a...

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